“He grinned, and right then it occurred to him that he hadn’t enjoyed himself so much with a woman in a very long time. If Annabelle Granger were a few inches taller, a hell of a lot more sophisticated, better organized, less bossy, and more inclined to worship at his feet, she’d have made a perfect wife.”

“There were long stretches of DNA in between genes that didn’t seem to be doing very much; some even referred to these as “junk DNA,” though a certain amount of hubris was required for anyone to call any part of the genome “junk,” given our level of ignorance.”

“I have been called arrogant myself in my time, and hope to earn the title again, but to claim that I am privy to the secrets of the universe and its creator — that’s beyond my conceit. I therefore have no choice but to find something suspect even in the humblest believer. Even the most humane and compassionate of the monotheisms and polytheisms are complicit in this quiet and irrational authoritarianism: they proclaim us, in Fulke Greville’s unforgettable line, “Created sick — Commanded to be well.” And there are totalitarian insinuations to back this up if its appeal should fail. Christians, for example, declare me redeemed by a human sacrifice that occurred thousands of years before I was born. I didn’t ask for it, and would willingly have foregone it, but there it is: I’m claimed and saved whether I wish it or not. And if I refuse the unsolicited gift? Well, there are still some vague mutterings about an eternity of torment for my ingratitude. That is somewhat worse than a Big Brother state, because there could be no hope of its eventually passing away.”

“I suppose that one reason I have always detested religion is its sly tendency to insinuate the idea that the universe is designed with ‘you’ in mind or, even worse, that there is a divine plan into which one fits whether one knows it or not. This kind of modesty is too arrogant for me.”

“When you pursue wisdom, you will soon realize how much you don’t know. Your knowledge will be incomplete, but continually developing through your curiosity. Arrogance blocks new information from coming in. When you’re conceited, you’ll resist change, and struggle to preserve your fixed image. Don’t fall into smug idleness, used to comfort. Challenge what you think you know, not caring if other people see you as a fool. Progress daily in your own uncertainty.”

“Any man who behaves arrogantly with what little he knows, or claims to know all, only reveals to all that he really knows nothing. Real greatness does not reside inside those who feel large. The truly wise are meek.”

“The only thing more dangerous than ignorance is the pretense of intelligent ignorance. The former is teachable; the latter is not.”

“People love answers, but only as long as they are the ones who came up with them.”

“Ah! how little knowledge does a man acquire in his life. He gathers it up like water, but like water it runs between his fingers, and yet, if his hands be but wet as though with dew, behold a generation of fools call out, ‘See, he is a wise man!’ Is it not so?”

“Do not be complacent about your achievements and not to strive for continual improvement when you get to the top. As soon as you let success go to your head, you sink into following familiar patterns and play it safe. In other words, you risk losing your edge.”

“I beseech you, in the bowels of Christ, think it possible you may be mistaken.”

“How can I claim to be the center of my universe when I can’t even conceptualize that which I claim to be the center of?”

“Vulnerable, like all men, to the temptations of arrogance, of which intellectual pride is the worst, he [the scientist] must nevertheless remain sincere and modest, if only because his studies constantly bring home to him that, compared with the gigantic aims of science, his own contribution, no matter how important, is only a drop in the ocean of truth.”